Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia (NCT04018287) | Clinical Trial Compass
UnknownNot Applicable
Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia
Austria60 participantsStarted 2017-08-01
Plain-language summary
The aim of the study is to accomplish a complete bone status of patients with HPP using new approaches to assess bone quality.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for Hypophosphatasia (HPP)
* genetically verified hypophosphatasia
* age \>18 years
* written informed consent
* complete serological and radiological examinations
Inclusion Criteria für Controls:
* healthy men and women without any history of musculoskeletal diseases
* written informed consent
* Alkaline phosphatase (AP) in reference range
* complete serological and radiological examinations
Exclusion Criteria for both Groups:
* inflammatory diseases
* other genetic disorders affecting bone such as osteogenesis imperfecta, Ehlers-Danlos-syndrome and fibrous dysplasia
* diabetes mellitus type 1 and 2
* COPD
* chronic kidney and liver dysfunction
* systemic glucocorticoid use and glucocorticoid induced osteoporosis
* eating disorders
* HIV-infections and any malignancy including plasmacytosis and lymphoma.
What they're measuring
1
HR-pQCT
Timeframe: Assessment once after Inclusion is completed.
2
microRNA pattern
Timeframe: Assessment once after Inclusion is completed