Pharmacokinetics and Pharmacodynamics of the Gametocytocidal and Post-treatment Chemoprotective Effects of Antimalarials

Inclusion Criteria: * Weight ≥10 kg * Any indication for malaria diagnostic testing as determined by a treating provider (e.g., fever or history of fever) * P. falciparum parasitemia (by microscopy) of any density not meeting criteria for severe malaria * Ability to swallow oral medication * Ability and willingness of parents or guardians to comply with study protocol for the duration of the study and to comply with the study follow-up visit schedule * Residence within hospital catchment area * Signed informed consent obtained from a legal representative of the participant Exclusion Criteria: * Complicated or severe falciparum malaria as defined by WHO criteria * Hemoglobin concentration \< 7 g/dL * Use of any drug with antimalarial activity within the prior 4 weeks * History of hypersensitivity reaction or intolerance to AL or DP * Co-infection with Plasmodium spp. other than P. falciparum as determined by microscopy * Confirmed or suspected concurrent acute infection other than malaria (e.g. measles, acute lower respiratory tract infection) * Current therapy with QT interval-prolonging agents * Family history of sudden cardiac death or personal history of cardiac disease * Residence outside the study area, or plan to leave the study area * Residence in foster care or otherwise under government supervision * Previous enrollment in the study, or enrollment in any other investigational drug trial during the previous 30 days * Presence of any other condition or abnormality t…