Oral Contraceptive Pill Compared With Vitamin E in Women With Migraine

Inclusion Criteria: * Female * Premenopausal with menstrual migraine OR migraine during the early menopausal transition phase (a difference of 7 days or more in length of consecutive cycles, which should occur at least twice in a period of 12 menstrual cycles) * Demonstrated at least 80% compliance with eDiary during baseline period * No or stable for at least two months on prophylactic medication Exclusion Criteria: * Smoking * Migraine with aura * Chronic migraine with 15 or more headache days per month/with 8 or more migraine days per month * Medication-overuse headache (ICHD-3 criteria) * Women who are breastfeeding, pregnant, or planning to become pregnant * Oral contraceptive use and not willing to undergo washout period (stop for two consecutive months) * Vitamin E use at start of the study * Use of other sex hormone containing treatments * Increased risk of VTE: history of VTE or thrombophlebitis, hereditary predisposition for VTE (APC resistance, protein C or S deficiency, antithrombin deficiency), VTE in first-degree family member at young age, long term immobilisation * Increased risk of ATE: history of ATE, hereditary predisposition for ATE (hyperhomocysteinemia, antiphospholipid antibodies), ATE in first-degree family member at young age, diabetes mellitus, total cholesterol ≥ 6.5 * Other contraindication for oral contraceptives: liver malignancy, schistosomiasis, HIV/aids, use of immunosuppressives, tuberculosis, sex-hormone-dependent malignancies (breast, en…