Juice Plus Inflammaging and Cardiovascular Disease Prevention Study

Inclusion Criteria: * 90 male and female subjects * age: 50 - 80 years * post- or peri-menopausal * Smokers and non-smokers * BMI 25 to 40 kg/m2 * Dietary Inflammatory Index, DII: 0 to +10 * Fruit and vegetable intake \<4 servings/d * Adherence to a 6-week "wash-out" period * Since the intervals between blood drawings are long (6 months), a temporary intake (e.g for a few days, one or two weeks) of some excluded drugs and food supplements does not necessarily mean exclusion from the study Exclusion Criteria: * Age \<50 and \>79.9 years * Dietary Inflammatory Index, DII: - 0.1 to -10 * Subjects with any kind of food allergy or histamine intolerance * Aversion to stop the intake of nutritional supplements and food, that could interfere with the study outcome * Food supplements, functional foods and dietetic products with anti-inflammatory or redox-biological relevance like omega-3 fatty acids, plant/herbal extracts/concentrates, vitamin- and mineral supplements * Fruit and vegetable intake \>3 servings per day * Hypertension, starting with grade 2 according to the classification of the European Society of Hypertension: systolic blood pressure \> 160 mmHg, diastolic blood pressure \>100 mmHg * Medication: any anti-inflammatory medication and medication with relevant antioxidant properties, blood pressure lowering medication, psychotropic drugs, immunosuppressives, cytostatics, anticoagulants, contraceptives, diuretics, pain medication * Clinically relevant infectious disease …