CompletedPhase 2

Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis

United States60 participantsStarted 2019-09-17

Plain-language summary

Randomized double blinded placebo-controlled trial to evaluate the impact of ovarian hyperstimulation on endometriosis-related symptoms and to evaluate the impact of letrozole use during ovarian hyperstimulation with respect to endometriosis-related symptoms, embryo/egg quality and quantity, and pregnancy rates.

Who can participate

Age range18 Years – 42 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-42 years * Planning to undergo controlled ovarian hyperstimulation * Prior diagnosis of endometriosis by one of the following: (1) surgical diagnosis (2) endometrioma on pelvic ultrasound * Planning to freeze all retrieved oocytes/embryos prior to transfer Exclusion Criteria: * Hypersensitivity to letrozole * Any significant concurrent disease, illness, or psychiatric disorder that would compromise patient safety or compliance, interfere with consent, study participation, follow-up, or interpretation of study results

What they're measuring

Average Delta in Endometriosis Pain Score Pre and Post Stimulation With and Without Use Of Letrozole

Timeframe: Baseline ultrasound (day 2 of menstrual cycle) and day 12 (average day of trigger shot).

Trial details

NCT IDNCT04002141

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-10-01

Results submitted2024-11-22

View on ClinicalTrials.gov More Endometriosis trials