Treatment Response of High-dose and Standard-dose Rabeprazole for Extra-esophageal Reflux. (NCT04001400) | Clinical Trial Compass
CompletedPhase 3
Treatment Response of High-dose and Standard-dose Rabeprazole for Extra-esophageal Reflux.
South Korea73 participantsStarted 2012-10-10
Plain-language summary
This is a single-center, randomized, open-label clinical study to assess the treatment response of high-dose rabeprazole compared with standard-dose rabeprazole in patients with extra-esophageal manifestations of gastroesophageal reflux disease.
Who can participate
Age range20 Years – 80 Years
SexALL
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Inclusion Criteria:
* Age is over 20 years old, under 80 years old, men or women
* Patients who had experienced extra-esophageal symptoms of gastroesophageal reflux disease more than once a week within the last month prior to the start of the study
Exclusion Criteria:
* Patients administered with prokinetics, H2 receptor antagonists, proton pump inhibitors, anticholinergic drugs or non-steroid anti-inflammatory drugs prior to study in 4 weeks
* Patients administered with anti-thrombotic drugs
* Patients taking other investigational drugs or participating in other clinical studies in 4 weeks
* Patients with esophageal stricture, esophageal varix, Barrett's esophagus, peptic ulcer or gastrointestinal bleeding
* Patients with Zollinger-Ellison syndrome
* Patients with any kind of malignant tumor
* Patients with surgery related to gastroesophageal
* Patients with significant cardiovascular, pulmonary, heptic, renal, hemopoietic or endocrine system primary disease
* Patients with neuropsychiatric disorder, alcoholism, or drug abuse
* Women either pregnant or breast feeding