The goal of this study is to assess the function of the lungs and the muscles are used to breathe after individuals receive respiratory training, spinal cord stimulation, a combination of respiratory training and stimulation, a combination of arm training and stimulation, or a combination of trunk training and stimulation. The respiratory, arm, and trunk training combined with the spinal stimulation interventions are being used to activate the spinal cord below the level of injury. Investigators will be looking for changes in the function of the lungs and trunk muscles before, during, and after these task-specific and non-task-specific interventions for breathing to determine which one has the greatest effect. The results of this study may aid in the development of treatments to help individuals with spinal cord injuries that have impaired lung, arm, and trunk function.
Who can participate
Age range18 Years – 99 Years
SexALL
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Inclusion criteria
✓. At least 18 years of age at the time of enrollment;
✓. Stable medical condition;
✓. Non-progressive SCI T5 or above;
✓. Sustained SCI at least 12 months prior to enrollment;
✓. At least a 15% deficit in pulmonary function outcomes (FVC or FEV1) as was detected by screening spirometry
Exclusion criteria
✕. Untreated musculoskeletal dysfunction;
✕. Unhealed fracture;
✕. Untreated contracture or pressure sore;
✕. Ventilator dependence;
✕. Untreated depression, psychiatric disorder, or ongoing drug abuse;
✕. Major pulmonary or cardiovascular disease;
What they're measuring
1
Non-invasive respiratory electromyography
Timeframe: Through study completion, an average of 1 year.
2
Spirometry
Timeframe: Through study completion, an average of 1 year.
3
Maximum airway pressure
Timeframe: Through study completion, an average of 1 year.