Resistance Training +/- Creatine for Metastatic Prostate Cancer Patients

Inclusion Criteria: * Metastatic prostate cancer patients who have not met criteria for disease progression on ongoing systemic therapy. * Currently treated with CYP17A1 inhibitors, surgical castration or medical castration with GnRH (gonadotropin-releasing hormone) agonists/antagonists, or androgen receptor blockers. Must have started the current regimen at least 12 weeks prior to enrollment. * Confirmation by the patient's treating oncologist that the patient is able to start the exercise program. * Regular access to an electronic device with internet service and ability for video calls (i.e. computer, smart phone, ipad, tablet, etc). * Access to an active MyChart account or the willingness to create an account for the purposes of the trial. * Must be able to read and understand English. * Willingness to engage in a home-based resistance exercise program two days per week. * If randomized to the creatine + resistance training group, willingness to take creatine monohydrate supplementation for the duration of the 12 week trial and avoid taking additional creatine-containing supplementation or other supplementation during the study period. * If randomized to the resistance training group without creatine supplementation, willingness to avoid taking creatine monohydrate supplementation or additional creatine-containing supplementation or other supplementation during the study period. * For participants randomized to the creatine arm willingness to complete and submit Weekly C…