Teripalimab Plus Chemotherapy in Local Advanced Esophageal Cancer

Inclusion Criteria: * Thoracic esophageal squamous cell carcinoma diagnosed by pathology * no distant metastasis, the diseases could be resected or potentially resectable assessed by thoracic oncologist * ECOG score 0-1 * clinical stage is stage II, III, and IVa according to AJCC 8.0 * expected lifespan \> 3 months * enough organ function * normal blood pressure, for patients with hypertension, the blood pressure should be controlled in normal level by antihypertension * the fasting blood sugar should be ≤ 8mmol / L for diabetic patients * no other serious diseases (such as autoimmune diseases, immunodeficiencies, organ transplants) that conflict with this study * no history of other malignant tumors * women of childbearing period must be tested negative for blood pregnancy within 7 days, and subjects of childbearing age must use appropriate contraceptive measures during the trial period and within 6 months after the trial; * The patient agrees to participate in the clinical study and sign the Informed Consent Form. Exclusion Criteria: * suffering from serious infectious diseases within 4 weeks before enrollment; * patients with bronchial asthma requires intermittent use of bronchodilators or medical interventions; * usage of immunosuppressants before the enrollment, the amount of immunosuppressant used ≥10mg / day oral prednisone for more than 2 weeks * clinically significant cardiovascular and cerebrovascular diseases, including but not limited to severe acute myocardial…