The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation

Inclusion Criteria: * Stenosis must be \>50% as determined by ultrasound or angiogram1 and the patient has a history of stroke (minor or non-disabling; NIHSS ≤4 or mRS ≤2), TIA and/or amaurosis fugax within 180 days of the procedure ipsilateral to the carotid artery to be stented. * Stenosis must be \>80% as determined by ultrasound or angiogram without any neurological symptoms within the prior 180 days. * Target vessel must meet diameter requirements for stent (refer to stent IFU for diameter requirements). * Patient has a discrete lesion located in the internal carotid artery (ICA) with or without involvement of the contiguous common carotid artery (CCA). * Patient is willing to comply with the protocol requirements and return to the treatment center for all required clinical evaluations. * Patient must have a life expectancy ≥ 3 years at the time of the index procedure without contingencies related to other medical, surgical or endovascular intervention. * Patient meets at least one of the surgical high-risk criteria listed in CMS National Coverage Determination (NCD) for Percutaneous Transluminal Angioplasty (20.7) Exclusion Criteria * Alternative source of cerebral embolus * Patient has chronic atrial fibrillation. * Patient has had any episode of paroxysmal atrial fibrillation within the past 6 months, or history of paroxysmal atrial fibrillation requiring chronic anticoagulation. * Knowledge of cardiac sources of emboli. e.g. left ventricular aneurysm, intracardiac…