Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Surviva… (NCT03981107) | Clinical Trial Compass
RecruitingNot Applicable
Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study
Italy, Sweden3,260 participantsStarted 2017-01-01
Plain-language summary
Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is associated with an increased chance of survival.
During the last decade, the best form of bystander CPR has been debated. Chest Compression Only CPR (CO-CPR) has been advocated as a preferable method in situations where the bystander has no previous knowledge in CPR, both because its believed to be equally efficient but also a simplified form of CPR that could lead to a higher incidence of bystander-CPR.
In an initiative to increase CPR rates the American Heart Association has launched public campaigns such as the "hands-only CPR" promoting CO-CPR as an option to S-CPR for adult non-asphyxic cardiac arrest. In the 2015 updates of the European resuscitation council guidelines it states that the confidence in the equivalence between the two methods is not sufficient to change current practice.
Whether CO-CPR leads to a survival rate no worse than, or even superior to standard CPR in situations where the bystander has previous CPR training remains unclear. This clinical question remains unanswered while millions of people are trained in CPR worldwide each year.
To investigate whether CO-CPR is non-inferior to standard CPR (S-CPR) when performed by a bystander with previous CPR training in witnessed, non-asphyxic cases of OHCA. Superiority testing will also be performed for the purpose of demonstrating a possible increase in survival with CO-CPR.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Unconsciousness with no, abnormal or agonal breathing (suspected OHCA)
* The suspected OHCA is witnessed (seen or heard)
* Any Bystander at the scene has previous training in CPR
Exclusion Criteria:
* Age below 18 years
* Collapse is not witnessed
* Bystander has no prior CPR training
* Obvious asphyxia (i.e. hanging, foreign body, suffocation, strangulation)
* Obvious drug overdose / intoxication
* Pregnancy
* Trauma (penetrating, blunt, burn injury)
Post randomisation exclusion Criteria from data analysis:
* Not EMS-verified cardiac arrest
* Previous do not resuscitate (DNR) decision
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing compression-only CPR to standard CPR with rescue breaths — if I or a family member experienced a cardiac arrest, does my doctor think one approach is more appropriate for my specific heart condition based on what's currently known?
2Since this trial is still recruiting and there's no completed phase data yet, what does my doctor think the current evidence says about whether compression-only CPR is as effective as standard CPR for someone in my situation?
3The trial measures survival at 30 days — can my doctor help me understand what happens after those 30 days, and whether the type of CPR received might affect longer-term recovery or brain function?
4If I or a loved one called 911 during a cardiac arrest while enrolled in this trial, how would the responding emergency team decide which CPR method to use, and would we have any say in that?
5Are there characteristics about my heart condition or health history that my doctor thinks would make one CPR method clearly preferable, which might mean a randomized trial like this isn't the right fit for me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.