A Dose Escalation Study of BLU-5937 in Unexplained or Refractory Chronic Cough

Inclusion Criteria: * Unexplained or refractory chronic cough for at least one year * Chest radiograph or CT thorax within the last 60 months not demonstrating any abnormality considered to be significantly contributing to the chronic cough * Cough count of ≥ 10 per hour (Awake Cough Count) at Screening * Score of ≥ 40mm on the Cough Severity VAS at Screening * Women of child-bearing potential must have a negative serum pregnancy test at Screening * Women of child-bearing potential must use a highly effective contraception method from Screening through the Follow-Up Visit * Male subjects and their partners of child-bearing potential must use 2 methods of acceptable birth control Exclusion Criteria: * Current smoker or individuals who have given up smoking within the past 6 months, or those with \>20 pack-year smoking history * Diagnosis of COPD, bronchiectasis, idiopathic pulmonary fibrosis * Treatment with an ACE-inhibitor as the potential cause of a subject's cough, or requiring treatment with an ACE-inhibitor during the study, or within 12 weeks prior to the Screening Visit * FEV1/FVC \< 60% * History of upper respiratory tract infection or recent significant change in pulmonary status within 4 weeks of the Baseline Visit * History of concurrent malignancy or recurrence of malignancy within 2 years prior to Screening * History of a diagnosis of drug or alcohol dependency or abuse within the last 3 years * Clinically significant abnormal electrocardiogram (ECG) or labora…