Adujvant CT+CRT vs Adujvant CT After D2 Resection for Locally Advanced Proximal Gastric Adenocarc… (NCT03973008) | Clinical Trial Compass
UnknownPhase 3
Adujvant CT+CRT vs Adujvant CT After D2 Resection for Locally Advanced Proximal Gastric Adenocarcinoma
China408 participantsStarted 2019-03-11
Plain-language summary
This study evaluates the addition of adjuvant chemoradiotherapy to adjuvant chemotherapy in the treatment of locally advanced proximal gastric adenocarcinoma after standard D2 radical resection.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion Criteria:
* Voluntary Participation and Written Signature of Informed Consent.
* Age 18-70, gender unlimited.
* Gross pathology confirmed that the tumor center was within 1 cm to 5 cm of the EGJ line. Histopathologically diagnosed as adenocarcinoma.
* No neoadjuvant therapy.
* Transabdominal standard D2 radical operation was performed and R0 resection was performed. Ascites cytology was negative.
* The pathological stages were IIB, IIIA, IIIB and IIIC.
* There was no intraperitoneal implantation and distant metastasis. CT should be routinely performed to evaluate the tumor bed before radiotherapy. Positron emission tomography (PET-CT) could be accepted to determine whether there was residual or distant metastasis.
* Physical condition score ECOG 0-1.
* No history of serious heart and lung diseases, abnormal hematological examination and immunodeficiency: hemoglobin (Hb) \> 9 g/dL; white blood cell (WBC) \> 3 x 109/L; neutrophil (ANC) \> 1.5 x 109/L; platelet (Pt) \> 100 x 109/L; bilirubin \< 1.5 times the upper limit of normal value; glutathione transaminase (ALT) \& alanine transaminase (AST) = 2.5 times the upper limit of normal value; serum creatinine \< 1.5 times the normal value Upper limit.
* No other systemic tumors were found.
* Fertile men or women are willing to take contraceptive measures in the trial.
* The daily energy intake is more than 1500 kcal.
Exclusion Criteria:
* Those who had a history of malignant tumors (except skin basal cell carcinoma, t…