TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection

Inclusion Criteria: * Subjects may be included in the study if they meet all of the following inclusion criteria: * Males or females, 18 years of age or older; * ABSSSI suspected or confirmed to be caused by gram-positive pathogens, including: * Cellulitis/erysipelas; * Wound infection; * Major cutaneous abscess; * Lesion with a minimum surface area of 75 cm2; * Capable of giving signed informed consent. Exclusion Criteria: * Subjects will be excluded from the study if any of the following exclusion criteria apply prior to randomization: * History or hypersensitivity or intolerability to any fluoroquinolone, rifamycin or glycopeptide classes; * ABSSSI suspected or confirmed to be caused by pathogens that are resistant to the glycopeptide class; * Prior administration of systemic antibacterial therapy within 96 hours before randomization; * ABSSSI with suspected or confirmed infection caused by gram-negative or anaerobic organisms; * ABSSSI with suspected or confirmed infection caused by fungal, mycobacterial, parasitic, or viral pathogens; * Evidence of significant hepatic, hematologic, or immunologic disease; * History or evidence of severe renal disease.