Treatment of Bile Acid Malabsorption With Liraglutide

Inclusion Criteria: * • Caucasian ethnicity * SeHCAT-verified moderate (5-10% bile acid retention after 7 days) or severe BAM (\<5% retention) * Normal haemoglobin (for men 8.3-10.5 mmol/L; for women 7.3-9.5 mmol/L) * Age above 18 years and below 75 years * Informed and written consent * BMI \>18,5 kg/m2 and \<40 kg/m2 * Glycated haemoglobin (HbA1c) \<48 mmol/mol Exclusion Criteria: * • History of or present hepatobiliary disorder (except for non-alcoholic steatotic liver disease) and/or alanine aminotransferase (ALAT) and/or serum aspartate aminotransferase (ASAT) \>3 times upper limit of normal) or history of hepatobiliary disorder * Gastrointestinal disease (except for BAM), previous intestinal resection or any major intra-abdomial surgery * Diabetes mellitus * Nephropathy with eGFR \< 60 mL/min/1.73m2 * Treatment with medicine that cannot be paused for 12 hours * Hypothyroidism or hyperthyroidism, if not well regulated. * Treatment with oral anticoagulants * Active or recent malignant disease * Any treatment or condition requiring acute or sub-acute medical or surgical intervention * Females of child-bearing potential who is pregnant (tested before entering the study), breastfeeding or intend to become pregnant or is not using adequate contraceptive methods, which includes Intrauterine Device (IUD), birth control pills, sexual abstinence or living in a relationship with a sterile partner. * Known or suspected hypersensitivity to trial …