The purpose of this study is to characterize the immune response in vivo using approved vaccines and antigen challenges, as well as a skin wounding challenge to stimulate the immune system.
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Cohort 1 and Cohort 2: Change from Baseline of Immune Cell Populations
Timeframe: Baseline up to 90 days
Cohort 3 and Cohort 4: Change from Baseline of Immune Cell Populations
Timeframe: Baseline up to 14 days
Cohort 5: Change from Baseline of Immune Cell Populations
Timeframe: Baseline up to 10 days
Cohort 1 and Cohort 2: Change from Baseline in Cell Surface Antigen Phenotype
Timeframe: Baseline up to 90 days
Cohort 3 and Cohort 4: Change from Baseline in Cell Surface Antigen Phenotype
Timeframe: Baseline up to 14 days
Cohort 5: Change from Baseline in Cell Surface Antigen Phenotype
Timeframe: Baseline up to 10 days
Cohort 1 and Cohort 2: Change from Baseline in Activation Status of Inflammatory Mediators (Soluble Cytokines and Chemokines)
Timeframe: Baseline up to 90 days
Cohort 3 and Cohort 4: Change from Baseline in Activation Status of Inflammatory Mediators (Soluble Cytokines and Chemokines)
Timeframe: Baseline up to 14 days
Cohort 5: Change from Baseline in Activation Status of Inflammatory Mediators (Soluble Cytokines and Chemokines)
Timeframe: Baseline up to 10 days
Cohort 1 and Cohort 2: Change from Baseline in Activation Status of Inflammatory Mediators (Cell-bound and Tissue-associated Proteins)
Timeframe: Baseline up to 90 days
Cohort 3 and Cohort 4: Change from Baseline in Activation Status of Inflammatory Mediators (Cell-bound and Tissue-associated Proteins)
Timeframe: Baseline up to 14 days
Cohort 5: Change from Baseline in Activation Status of Inflammatory Mediators (Cell-bound and Tissue-associated Proteins)
Timeframe: Baseline up to 10 days
Cohort 1 and Cohort 2: Change from Baseline in Expression of Inflammatory Mediators
Timeframe: Baseline up to 90 days
Cohort 3 and Cohort 4: Change from Baseline in Expression of Inflammatory Mediators
Timeframe: Baseline up to 14 days
Cohort 5: Change from Baseline in Expression of Inflammatory Mediators
Timeframe: Baseline up to 10 days