Effect of Lifitegrast 5% on Tear Film Markers

Inclusion Criteria: * Signs or symptoms of Dry Eye Disease * 18 years or older * Abnormal MMP9 (positive as read by 2 blinded investigators with both in agreement) and/or Abnormal tear osmolarity (greater than or equal to 308 or an inter-eye difference \>=8 mOsm/mL) Exclusion Criteria: * Active eye infection. Patients with blepharitis may be enrolled. * Any eye drop that was instilled within 2 hours of the Baseline eye exam * Current contact lens wearer. Subjects who have not worn contact lenses 30 days prior to baseline and have no intention to wear CLs during the study duration may enroll. * History of ocular herpes simplex * Active episcleritis, scleritis, iritis or uveitis * Active keratitis secondary to any etiology other than dry eyes * History of refractive surgery (LASIK or PRK) or penetrating corneal transplant (PK) * Uses eye drops (ex. glaucoma or allergy drops) for indications other than dry eyes * Active allergic conjunctivitis * Current use of punctal plugs or anticipation of use during the study * Use of topical ophthalmic steroids within 14 days of the Baseline Visit or anticipated use during the study * Use of lifitegrast 5% or Restasis within 30 Days of the Baseline Visit. * Allergy to lifitegrast 5%