Surgical Intervention With DermaPure vs Native Tissue in Pelvic Organ Prolapse

Inclusion criteria: * Subject is female * Subject is at least 18 years of age * Subject has prolapse of the anterior compartment beyond the hymen * Subject reports bulge symptoms as defined in question 3 of the PFDI-20 with a response of 2 or higher ("somewhat", "moderately" or "quite a bit") * Subject is willing and able to provide informed consent * Subject is willing and able to comply with the follow-up protocol through 36 months Exclusion criteria: * Subject is pregnant or intends to become pregnant during the study * Subject has untreated severe urogenital atrophy * Subject has an active or chronic systemic infection including any gynecologic infection, untreated urinary tract infection (UTI), or tissue necrosis * Subject has a history of pelvic organ cancer (e.g. uterine, ovarian, bladder, or cervical) * Subject has had prior pelvic radiation therapy * Subject has taken systemic steroids within the last month, or immunosuppressive or immunomodulatory treatment within the last 3 months (list attached) * Subject has a history of poor wound healing with or without a diagnosis of connective tissue disease * Subject has chronic systemic pain that includes the pelvic area or chronic focal pain that involves the pelvis * Subject has uncontrolled diabetes mellitus (DM) as defined by a hemoglobin A1C \< or = to 8% (Underwood, Ata) * Subject has a known neurologic or medical condition that may effect of currently affects bladder function * Subject is seeking obliterative vagi…