CompletedPhase 4

Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment

48 participantsStarted 2006-01-01

Plain-language summary

This study is designed as a parallel, masked, randomized, placebo-controlled clinical trial to assess the clinical, microbiological, and immunological outcomes of scaling and root planning (SRP) or full-mouth ultrasonic debridement (FMUD) with AM (Amoxicillin + Metronidazole) for the treatment of Generalized Aggressive Periodontitis (GAgP).

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * diagnosis of GAgP; * presence of 20 teeth; * presence of teeth presenting PD\>5 mm with bleeding on probing (BOP) and 2 teeth with PD\>7mm (including incisors and first molars, in addition to two other non-contiguous teeth between them); * good general health; * \<35 years of age. Exclusion Criteria: * were pregnant or lactating; * were suffering from any other systemic diseases (e.g., cardiovascular, diabetes); * received antimicrobials in the previous 3 months; * were taking long-term anti-inflammatory drugs; * received a course of periodontal treatment within the last 6 months; * smoked

What they're measuring

Change of the baseline relative clinical attachment level at 6 months

Timeframe: Baseline, 3 months and 6 months

Trial details

NCT IDNCT03933501

SponsorUniversity of Campinas, Brazil

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-12-01

View on ClinicalTrials.gov More Generalized Aggressive Periodontitis trials