Botanical Tincture for Symptoms of Irritable Bowel Syndrome

Inclusion Criteria: * Patients meeting ROME IV criteria for the diagnosis of irritable bowel syndrome that requires that patients have had recurrent abdominal pain on average at least 1 day per week during the previous 3 months that is associated with 2 or more of the following : * Related to defecation (may be increased or unchanged by defecation) * Associated with a change in stool frequency * Associated with a change in stool form or appearance * Abdominal Pain Intensity: average of worst daily (in past 24 hours) abdominal pain score of \>= 3 on a 0 to 10 point scale over last week * Stool Frequency: \< or = to 3 Complete Spontaneous Bowel Movement(CSBM) in the previous week * Reported bloating rating \> or = 2 on 5-point scale \[0 (absent) - 4 (very severe)\] in previous week * English speakers, as all surveys are in English Exclusion Criteria: * Patients with known hypersensitivity to any component of the trial drugs * History of eating disorders * Patients with a history of diseases with abdominal symptoms that can resemble IBS * Presence of any other known acute or chronic gastrointestinal disorder * History of abdominal surgery (cholecystectomy and appendectomy can be tolerated when performed at least one year previously) * Pregnancy or breast feeding * Current or past history of alcohol dependence * Based on lack of adequate scientific evidence to predict drug-drug interaction in vivo, current use of strong inhibitors or inducers for CYP enzymes and participants a…