Building upon the clinical experience of the investigators with the magnetic resonance (MR)-guided radiation therapy system and applying principals of hypofractionation toward the current treatment paradigm of concurrent chemoradiation and consolidation immunotherapy for locally advanced non-small cell lung cancer (NSCLC), this prospective, single-arm Phase II clinical trial with safety lead-in will test the feasibility and outcomes of this approach.
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Safety lead-in only: Number of participants with dose limiting toxicities (DLTs)
Timeframe: Through 6 months after completion of concurrent chemoradiation (estimated to be 6 months and 3 weeks)
Local control rate (Phase II only)
Timeframe: Through 2 years after start of chemoradiation (estimated to be 2 years and 3 weeks)
Regional control rate (Phase II only)
Timeframe: Through 2 years after start of chemoradiation (estimated to be 2 years and 3 weeks)