Efficacy and Safety of Increasing Doses of DaxibotulinumtoxinA for Injection (DAXI for Injection) in the Treatment of Moderate or Severe Lateral Canthal Lines

Inclusion Criteria: * Provide written informed consent consistent with International Conference on Harmonisation (ICH)-Good Clinical Practice (GCP) guidelines and local laws, including authorization to release health information, signed prior to any study procedures being performed * Be outpatient, male or female subjects, in good general health, 18-65 years old * Have a score of moderate (2) or severe (3) LCL at maximum smile effort as assessed by the IGA-LCWS * Able to understand the requirements of the study and be willing and able to follow all study procedures, attend all scheduled visits, and successfully complete the study. Exclusion Criteria: * Active skin disease, infections, or inflammation at the injection sites * History of clinically significant bleeding disorders * Clinically significant laboratory values at screening that may interfere with a subject's ability to complete the study, as determined by the investigator * Planned or anticipated need for surgery or hospitalization through the end of the study * Pregnant, nursing, or planning a pregnancy during the study; or is Women of Child Bearing Potential (WOCBP) but is not willing to use an effective method of contraception * Current enrollment in an investigational drug or device study or participation in such a study within the last 30 days prior to screening through the end of the study