Proton Pump Inhibitor Preventing Upper Gastrointestinal Injury In Patients On Dual Antiplatelet Therapy After CABG

Exclusion criteria

• ✕. Provision of signed informed consent prior to any study specific procedures.
• ✕. Male or female, age ≥ 18 years at the time of consent.
• ✕. Planned or initiated use of 12 months of DAPT (aspirin plus clopidogrel or aspirin plus ticagrelor) immediately following primary isolated elective CABG surgery.
• ✕. History of previous active peptic ulcer within 3 months prior to enrollment.
• ✕. Planned use of PPIs to treat acid-associated disorders (e.g. gastroesophageal reflux disease, GERD)
• ✕. Contraindications for aspirin, clopidogrel, ticagrelor and pantoprazole use (e.g. known allergy)
• ✕. Anticipated concomitant oral or intravenous therapy with strong cytochrome P450 3A4 (CYP3A4) inhibitors or CYP3A4 substrates with narrow therapeutic indices, that cannot be stopped for the course of the study.
• ✕. Need for chronic oral anticoagulant therapy or chronic low-molecular-weight heparin.