Oxytocin Receptor Expression in Pregnancy (NCT03907735) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Oxytocin Receptor Expression in Pregnancy
United States30 participantsStarted 2019-06-03
Plain-language summary
This study aims to determine when during gestation oxytocin receptor (OXTR) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and abnormal labor.
Who can participate
Age range18 Years – 50 Years
SexFEMALE
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Inclusion Criteria:
* Women age 18-50
* Gestational age 14-26 weeks; or 6-13 weeks, 37-42 weeks, or non-pregnant (controls)
* Undergoing another planned surgical procedure with anesthesia (suction D\&C, D\&E, gravid hysterectomy, cesarean section, or laparoscopic tubal ligation)
* Able to give informed consent in English or Spanish
Exclusion Criteria:
To optimize biopsy safety, we will exclude patients with anticipated difficult cases, that have additional risks of hemorrhage, or those with features that limit ultrasound visualization.
Increased risk of hemorrhage:
* Anemia (Hgb \< 9)
* Anticoagulation, bleeding disorder, or coagulopathy
* Multiple gestation
* Infection or sepsis
For ultrasound-guided procedures:
* Obese, BMI ≥ 40
* History of ≥2 cesarean sections
* Large fibroids or uterine anomalies obstructing view
* Other poor visualization
* Thin myometrium \< 1cm