Identification of microRNAs Involved in Cerebral Collateral Regulation (NCT03905434) | Clinical Trial Compass
SuspendedNot Applicable
Identification of microRNAs Involved in Cerebral Collateral Regulation
Stopped: PI moved from OSU to VCU. Study is suspended pending credentialing and IRB approval at VCU.
United States45 participantsStarted 2018-08-14
Plain-language summary
Patients \>18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will be included in this study. The purpose of this study is to evaluate the differential expression of exosomal microRNAs in patients with stroke due to acute LVO as compared to healthy controls. In addition, the investigators will also evaluate the differential expression of exosomal microRNA in patients with good vs poor collateral grade.
Who can participate
Age range18 Years â 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
â. Age 18 years or older.
â. Diagnosis of Acute Ischemic Stroke secondary to LVO
â. LVO from presumed embolic source (\<50% ICA)
â. CT perfusion/RAPID images showing salvageable penumbra (evaluated by PI)
Exclusion criteria
â. \>50% stenosis of internal carotid artery
â. \>50% stenosis of bilateral vertebral arteries.
â. Patients with moderate to severe intracranial atherosclerotic disease as seen in CTA of head and neck.
â. Known moderate to severe PVD or symptomatic CAD
â. Past medical history of stent or coronary artery bypass surgery
â. Prisoners
â. Pregnant women
What they're measuring
1
identification of differentially expressed microRNAs in patients with sudden acute anterior circulation large vessel occlusion, compared to healthy controls.