SuspendedNot Applicable

Identification of microRNAs Involved in Cerebral Collateral Regulation

Stopped: PI moved from OSU to VCU. Study is suspended pending credentialing and IRB approval at VCU.

United States45 participantsStarted 2018-08-14

Plain-language summary

Patients \>18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will be included in this study. The purpose of this study is to evaluate the differential expression of exosomal microRNAs in patients with stroke due to acute LVO as compared to healthy controls. In addition, the investigators will also evaluate the differential expression of exosomal microRNA in patients with good vs poor collateral grade.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Age 18 years or older.
. Diagnosis of Acute Ischemic Stroke secondary to LVO
. LVO from presumed embolic source (\<50% ICA)
. CT perfusion/RAPID images showing salvageable penumbra (evaluated by PI)

Exclusion criteria

. \>50% stenosis of internal carotid artery
. \>50% stenosis of bilateral vertebral arteries.
. Patients with moderate to severe intracranial atherosclerotic disease as seen in CTA of head and neck.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

identification of differentially expressed microRNAs in patients with sudden acute anterior circulation large vessel occlusion, compared to healthy controls.

Timeframe: 2 years

Trial details

NCT IDNCT03905434

SponsorVirginia Commonwealth University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-12-01

View on ClinicalTrials.gov More Cerebrovascular Disorders trials