A Study of Safety and Primary Immunogenicity of 9-valent HPV Recombinant Vaccine

Inclusion Criteria: * Healthy females, 9 to 45 years old (inclusive). * 9 to 17 years old participants: able to prove their identities and provide their legal guardians' identity information. * Legal guardians of the 9 to 17 years old participants: able to understand (not illiterate) and agree to co-sign the informed consent forms with participants * 18 to 45 years old participants: able to prove their legal identities. * 18 to 45 years old participants: able to understand (not illiterate) the study and agree to sign the informed consent form. * Child bearing age participants: agree not to become pregnant by using proper contraception means in the 7-month study period. Exclusion Criteria: * History of cervical cancer or genital warts. * History HPV vaccination or history of participation in HPV vaccine trial. * History of severe allergy which needs medical intervention such as swelling of the mouth and throat, difficulty breathing, hypotension or shock. * Skin abnormality at injection site including inflammation, sclerosis, redness, swelling, and extensive scars. * History of allergy to vaccine or vaccine components including aluminum phosphate, histidine and Polysorbate 80, and severe adverse reactions in past vaccination. * Medical history of epilepsy, convulsions, seizures , or family history of mental illness. * Medical conditions including immunocompromised or diagnosed as congenital or acquired immunodeficiency, HIV infection, lymphoma, leukemia, systemic lupus eryth…