Safety & Immunogenicity Study of Ad5 Based Oral Norovirus Vaccines

Inclusion Criteria: * Male or female between the ages of 18 to 49 years, inclusive * General good health, without significant medical illness, based on medical history, physical examination, vital signs, and clinical laboratories * Demonstrate comprehension of the protocol procedures and willingness to adhere to all visits and assessments * Body mass index between 17 and 35 at screening * Female subjects must have a negative pregnancy test at screening and before each vaccination and fulfill protocol specified criteria for adequate birth control. Exclusion Criteria: * Presence of a significant medical condition which in the opinion of the investigator precludes participation in the study * History of cancer or cancer treatment within past 3 years * Presence of immunosuppression or medical condition possibly associated with impaired immune responsiveness, including diabetes mellitus or angioedema * Donation or use of blood/blood products within 4 weeks prior to vaccination * Diagnosed bleeding disorder or significant bruising or bleeding difficulties that could make blood draws problematic. * Any condition that resulted in the absence or removal of the spleen * Positive HIV, HBsAg or HCV tests at the screening visit * Use of antibiotics, proton pump inhibitors, H2 blockers or antacids within 7 days of vaccination * Use of medications known to affect the immune function within 14 days of vaccination * Use of NSAIDs, sulfonylureas, and angiotensin II blockers within 7 days of…