The Effect of Intra-articular Bilateral Knee Injections of Zilretta on Performance Measures in Adults With Knee OA

Inclusion Criteria: * Men and women age 30 years or older with symptomatic bilateral knee OA * Symptomatic knee OA will be defined as the presence of a definite osteophyte or joint space narrowing (KL Grade ≥2) on posteroanterior (PA) fixed flexion knee radiographs in subjects limited by bilateral pain rated on a Numerical Rating Scale as ≥ 4/10 on more than half of the days over the past month. Radiographic change must be visible at standard image size, irrespective of capability to detect more subtle changes through digital enhancement. * Bilateral knee symptoms for ≥ 3 months prior to screening * Has undergone at least one prior conservative osteoarthritis treatment (e.g. Physical therapy, analgesics) * Body Mass Index ≤ 41 kg/m2 * Ambulatory * Willing and able to comply with the study procedures and visit schedules and ability to follow verbal and written instructions. * Willingness to abstain from the use of protocol-restricted medications during the study after signing informed consent and also willing to abstain from use of all analgesics other than acetaminophen 1 week prior to beginning of treatment. Exclusion Criteria: * Current consumption of more than 14 alcoholic drinks per week * Clinical signs and symptoms of active knee infection or crystal disease of either knee within 1 month of screening * Diagnosed with rheumatoid arthritis, Reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis, or arthritis secondary to other inflammatory diseases; HIV, …