CompletedPhase 4

Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl

Norway12 participantsStarted 2019-04-23

Plain-language summary

The aim of this study is to determinate the equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl.

Who can participate

Age range18 Years – 64 Years

SexALL

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Inclusion criteria

✓. Healthy volunteers
✓. Age 18 - 64
✓. Both sex
✓. No chronic disease
✓. No regular medication
✓. Recruited from the general population
✓. Signed informed consent and expected cooperation of the subjects for the treatment and follow up must be obtained and documented according to ICH GCP, and national/local regulations

Exclusion criteria

✕. Use of pain medication the last 2 days before a session
✕. Use of complementary medicine the last 2 days before a session
✕. Use of regular medication
✕. Previous substance abuse
✕. Pregnancy
✕. Know allergies or serious side effects to opioids or metoxyflurane
✕. Use of alcohol last 24 h before each session
✕. Exclusion criteria with respect to fentanyl:

What they're measuring

NRS (numeric rating scale) scores during the second CPT, which starts 5 minutes after drug administration and lasts for 90 seconds. NRS is a scale from 0 to 10 (0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10). 0 = no pain and 10 = worst pain imaginable.

Timeframe: 90 seconds

Trial details

NCT IDNCT03894800

SponsorOslo University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-10-29

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