Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers

Inclusion Criteria: * Meets the International Study Group criteria for Behcet's Disease * Presents with at least one active lesions accessible to measurement, the largest of which is to be designated as the index ulcer * Index oral ulcer to be assessed should be in the easily accessible areas of the oral mucosa, and the oral ulcer first began within 48 hrs prior to enrollment * Adult (\>18 years) male or a non-pregnant, non-lactating female * Has signed an Ethics Committee (EC) approved subject consent form * Has completed all screening procedures satisfactorily, is deemed to be an acceptable subject and is otherwise eligible for entry into the study * Is willing and able to comply with the protocol * Is being treated with colchicine Exclusion Criteria: * Has a severe, acute, or chronic systemic disease other than Behcet's Disease such as congestive heart failure, hepatic failure, renal failure, systemic lupus erythematosus, Stevens-Johnson syndrome, ulcerative colitis, cancer, leukemia, diabetes, AIDS, or any other condition that is severely compromising the immune system * Has received pentoxifylline in any form over the previous 60 days prior to enrollment * Has experienced recent cerebral and/or retinal hemorrhage or in patients who have previously exhibited intolerance to pentoxifylline or methylxanthines such as caffeine, theophylline, and theobromine * Has concomitant administration of strong CYP1A2 inhibitors (including e.g. ciprofloxacin or fluvoxamine) and other …