Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic Neoplasma （GTN） Patients With Score of 5-6

Inclusion Criteria: * Clinical diagnosis of gestational trophoblastic tumor; * Patients with prognosis score of 5 and 6 * Primary chemotherapy (preventive chemotherapy is not included); * Physical strength grade: Karnofsky score ≥ 60; * WBC ≥ 3.5× 109/L, ANC ≥ 1.5× 109/L, PT ≥ 80× 109/L, serum bilirubin ≤ 1.5 times of normal high limit, transaminase ≤ 1.5 times of normal high limit, BUN, Cr≤ normal; * Follow-up and good compliance; * Sign the informed consent form. Exclusion Criteria: * Pathological diagnosis is intermediate trophoblastic tumor, including PSTT and ETT； * There are serious or uncontrollable medical diseases, which are not suitable for chemotherapy; * Those who receive clinical trials of other drugs at the same time. * Those who receive Chinese medicine.