StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberculosis

Inclusion Criteria: * 18 years of age or older * Clinical signs and symptoms of pulmonary tuberculosis * Abnormal chest radiograph consistent with pulmonary tuberculosis * At least one sputum positive for M. tuberculosis by Xpert MTB/RIF with a cycle threshold (Ct) less than 28. * Documentation of HIV status * Weight greater than or equal to 45 kg * Karnofsky score of at least 60 * Ability to provide informed consent * Ability to adhere to study follow-up visits * Negative pregnancy test in women of child-bearing age * Ability to adhere to contraceptive requirements and willing to use two forms of contraception: 1) a double barrier method to prevent pregnancy (i.e. use of a condom with either diaphragm or cervical cap) or 2) use of an intrauterine device in combination with a barrier contraceptive. The participant must be willing to continue these contraceptive measures throughout the duration of the study and until one week after the last dose of study medication or one week after discontinuation from study medication in case of premature discontinuation. * Five days or fewer of anti-tuberculosis treatment within the previous 3 months Exclusion Criteria: * A history of severe adverse reactions to any statin or any other study agent or contraindications to use of statins. * Current use of statins or other lipid-lower agents; * Clinical indication for statin therapy based on cardiovascular risk: * Familial hypercholesterolemia * Previous history of myocardial infarctio…