BM-MNCs for Lower Extremity Compartment Syndrome Injury

Inclusion Criteria: * Females and males 18 - 70 years old * Has single or multiple compartment syndrome of the lower leg that includes the anterior tibial compartment * Trauma patients with lower extremity CS requiring fasciotomy that can be treated with autologous BM-MNC therapy on day 5-9 post-fasciotomy * Ability to sign an informed patient consent form * Access and willingness to complete a standard of care course of rehabilitation therapy and 24 months follow-up evaluations * Ability to close the fasciotomy wound per physician assessment * Anterior compartment muscle volume between 100 - 280 cc as determined by MRI/CT * Within the institutions' clinical reference ranges for HbA1C * Negative HIV test · - Non-fracture, closed fracture or compound fracture type I (wound less than 1cm \& compound from within out) (Gustilo-Anderson classification) * Female subjects must be of non-childbearing potential or must be using adequate contraception * If female subject is of childbearing potential, subject must have a negative pregnancy test at screening * Willing and able to adhere to the study schedule Exclusion Criteria: * Prior compartment syndrome of same limb; * Active malignancy or has undergone treatment for a malignancy in the preceding 5 years as indicated in past medical history or self-report if medical records do not accompany subject or are unable to be collected (basal cell carcinoma non-exclusionary); * HIV positive as indicated by past medical history, self-rep…