Cardiovascular Status in Patients With Endogenous Cortisol Excess (Cushing's Syndrome) (NCT03880513) | Clinical Trial Compass
CompletedNot Applicable
Cardiovascular Status in Patients With Endogenous Cortisol Excess (Cushing's Syndrome)
Germany108 participantsStarted 2014-10
Plain-language summary
Within this trial, the cardiovascular and mental status as well as the metabolic profiles of patients with endogenous cortisol excess are evaluated.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Written informed consent
* Age ≥18 years
* Cross-sectional study:History of clinically and biochemically proven endogenous Cushing's syndrome (overt or subclinical)
* Longitudinal study: Patients with clinically and biochemically proven endogenous Cushing's syndrome (initial diagnosis or recurrent disease)
Exclusion Criteria:
* Glucocorticoid pharmacotherapy for \>12 months within the previous 3 years
* Structural heart disease, chronic heart failure (\>NYHAII), systemic or single organ disease potentially affecting cardiac function
* Arterial hypertension (uncontrolled with \>3 antihypertensive drugs)
* Pregnancy
* Drug abuse
* Cardiac Magnetic Resonance Imaging (cMRI) substudy: patients with renal failure are excluded from the cMRI study (MDRD \<60)