VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults

Inclusion Criteria: A volunteer must have met all of the following criteria: * Age 18 to 50 years * Available for clinical follow-up through 36 weeks after randomization * Able to provide proof of identity to the satisfaction of the study clinician completing the enrollment process * Able and willing to complete the informed consent process * Willing to donate blood for sample storage to be used for future research * In good general health, without clinically significant medical history, and has satisfactorily completed screening * Physical examination and laboratory results without clinically significant findings within the 28 days prior to randomization Laboratory Criteria within 28 days prior to randomization: * Hemoglobin within institutional normal range or accompanied by Principal Investigator (PI) or designee approval * White blood cell (WBC) and differential either within institutional normal range or accompanied by PI or designee approval * Total lymphocyte count: ≥800 cells/mm3 * Platelets: 125,000-500,000/mm3 * Alanine aminotransferase (ALT): ≤ 1.25 x upper limit of normal range * Serum creatinine: ≤1.1 x upper limit of normal * Negative for HIV infection by an FDA-approved method of detection Criteria applicable to women of childbearing potential: * Negative beta-human chorionic gonadotropin (β-HCG) pregnancy test (urine or serum) on day of randomization before receiving the study product * Agrees to use an effective method of birth control, if sexually acti…