CompletedEarly Phase 1

4-methylpyrazole and Acetaminophen Metabolism

United States6 participantsStarted 2018-07-01

Plain-language summary

Oxidative metabolism of APAP will be studied with and without 4-MP.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy * No APAP use in previous 2 weeks * No ingestion of alcohol or drugs that affect CYP 2E1 over previous 5 days * No allergy to APAP or fomepizole * BMI \< 29 Exclusion Criteria: * Pregnant or lactating * History of alcohol abuse * Allergy to APAP or fomepizole * Screening LFTs above normal range

What they're measuring

Oxidative metabolism of APAP

Timeframe: 24 hours

Trial details

NCT IDNCT03878693

SponsorUniversity of Arizona

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-10-31

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