Treatment With Allogeneic Adipose-derived Mesenchymal Stem Cells in Patients With Aqueous Deficient Dry Eye Disease

Inclusion Criteria: * OSDI-score \> 30 * Schirmer's test 2-5 mm in 5 minutes * TBUT \< 10 sec. Exclusion Criteria: * Previously established allergies to Oxybuprocaine or DMSO (rare) * Reduced immune response (e.g. HIV positive) * Pregnancy or planned pregnancy within the next 2 years * Breastfeeding * Treatment with an anticoagulant that cannot be stopped during the intervention period * Treatment with systemic medication known to reduce tear production (with an odds ratio \>2,0 (3)): anxiolytics, antipsychotics, and inhaled steroids. * Topical treatment with eye drops other than lubricants * Any other disease/condition judged by the investigator to be grounds for exclusion, such as infection in or around the eye