Genetics of Spontaneous Coronary Artery Dissection (SCAD-INSPIRE Genetics)
100 participantsStarted 2016-10-17
Plain-language summary
Spontaneous coronary artery dissection (SCAD) is a rare cause of coronary ischemia and infarction where a tear in blood vessel wall either restricts the flow of blood or the blood becomes trapped in between the layers of the vessel causing the vessel to impinge on the lumen and causing an obstruction or restriction of blood flow. The ultimate goal of this proposal is to further understand the risk factors leading to SCAD with a focus on familial and genetic causes of SCAD.
Who can participate
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Subjects of all ages, gender, or race
✓. Subjects had coronary angiography.
✓. Subjects had suspected SCAD as based on clinical report.
✓. INSPIRE subject that had coronary angiography at Intermountain Healthcare for stable angina.
✓. Subjects had no or mild atherosclerotic heart disease at time of angiography.
✓. Age at last visit as recorded in the Intermountain EDW at least 50 years or older.
✓. Not screened as possibly having a SCAD or coronary artery dissection diagnosis.
Exclusion criteria
✕. Independent review of cardiac imaging and clinical presentation by three cardiologists determine the coronary angiography was not a result of SCAD.
✕. Imaging from time of coronary angiography of poor quality as to not allow for proper determination of SCAD.
✕. Inability to determine criteria as outlined above.
✕. Subjects that have had a heart transplant.
✕. Subjects that have had a bone marrow transplant.
✕. Inability or refusal of the patient and/or the patient's legally acceptable representative to provide informed consent or blood sample for any reason.