Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET

Inclusion Criteria (for all subjects): * Written informed consent must be obtained before any assessment is performed. * Provide signed and dated written informed consent. * Female subjects must be documented by medical records or physician's note to be either surgically sterile (by means of hysterectomy, bilateral oophorectomy, or tubal ligation) or post-menopausal for at least 1 year or, if they are of child-bearing potential, must commit to the use of a barrier method of contraception for the study duration, * Male subjects and their partners of childbearing potential must commit to the use of a barrier method of contraception for the study duration. * Male subjects must not donate sperm for the study duration. * Able to lie supine on camera bed for a reasonable period of time. * Willing and able to cooperate with study procedures. * Women of child bearing potential must have a negative pregnancy test at screening. Inclusion criteria specific to healthy volunteer subjects: * Males and females aged 45-80 years, healthy with no clinically relevant finding on physical examination at screening and upon reporting for the \[18F\]PBR06 imaging sessions. * No family history of ALS or frontotemporal dementia. * C-reactive protein level ≤10 mg/dL Inclusion criteria specific to ALS subjects * Males and females aged 18 to 80 years. * Sporadic or familial ALS diagnosed as possible, laboratory-supported probable, probable, or definite as defined by the modified El Escorial criteria; …