RecruitingNot Applicable

Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

United States30 participantsStarted 2019-08-01

Plain-language summary

It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * BMI 40 - 50 kg/m2. * Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery Exclusion Criteria: * Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL * Active coronary artery disease * Participation in structured exercise (\>2 times per week for 30 minutes or longer) * Smoking * Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids) * Renal insufficiency (serum creatinine \> 1.5mg/dl) * Chronic active liver disease (Bilirubin \> 17mmol/L, AST \> 144 IU/L, or ALT\>165IU/L) * Pregnancy or breastfeeding.

What they're measuring

adipose macrophage content, adipose IL-6 and TNF gene expression

Timeframe: Before bariatric surgery and approximately 1 year after surgery

insulin regulation of lipolysis (IC50)

Timeframe: Before bariatric surgery and approximately 1 year after surgery

Trial details

NCT IDNCT03868592

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-05

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