CompletedPhase 4

Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery

United States45 participantsStarted 2019-08-22

Plain-language summary

This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery. Half of participants will receive a ketamine infusion during surgery, while the other half will receive a placebo (normal saline) during surgery.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion Criteria: * Patient presenting for non-cardiac, non-intracranial surgery * Major Depressive Disorder Exclusion Criteria: * Pregnant of breastfeeding women

What they're measuring

Montgomery-Asberg Depression Rating Scale (MADRS) Score

Timeframe: Post-intervention days 1, 2 and 3

Trial details

NCT IDNCT03861988

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-09-22

Results submitted2023-09-03

View on ClinicalTrials.gov More Major Depressive Disorder trials