CompletedPhase 1

Sleep and Healthy Aging Research on Depression for Younger Women

United States40 participantsStarted 2019-10-02

Plain-language summary

Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood. This study comprehensively evaluates effects of inflammation on reward across dimensions (e.g., anticipating versus receiving a reward) and types (e.g., money vs. smiling faces) in younger and older women. Characterizing how inflammation shapes the dynamic and multidimensional reward system, and how this may differ by age, may give insight into risk factors for depression and help identify critical points for intervention.

Who can participate

Age range25 Years – 44 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participants will be required to be in good general health (as evaluated during the phone and in-person baseline session) * Participants will be biologically female and premenopausal (as evaluated by self report). * Participants will 25-44 years of age. Exclusion Criteria: * Presence of chronic mental or physical illness * History of allergies, autoimmune, liver, or other severe chronic diseases, * Current and regular use of prescription medications such as steroids, non-steroid anti-inflammatory drugs, aspirin, immune modifying drugs, opioid analgesics, statins, antihypertensive drugs, anti-arrhythmic drugs, and antidepressant medications (none in the last 6 months). * Nightshift work or time zone shifts (\> 3hrs) within the previous 6 weeks * Previous history of fainting during blood draws. * Presence of co-morbid medical conditions not limited to but including cardiovascular (e.g., history of acute coronary event, stroke) and neurological diseases (e.g., Parkinson's disease), as well as pain disorders; * Presence of comorbid inflammatory disorders such as rheumatoid arthritis or other autoimmune disorders; * Presence of an uncontrolled medical condition that is deemed by the investigators to interfere with the proposed study procedures, or to put the study participant at undue risk; * Presence of chronic infection, which may elevate proinflammatory cytokines; * Presence of an acute infectious illness in the two weeks prior to an experimental sessio…

What they're measuring

Non-social (Monetary) Reward Response (Reward Learning and Sensitivity)

Timeframe: Baseline and post-injection (2.25 hrs)

Non-social (Monetary) Reward Response (Reward Motivation)

Timeframe: Baseline and post-injection (2.1 hrs)

Non-social (Monetary) Reward Response (Reward Sensitivity)

Timeframe: Baseline and post-injection (2.1 hrs)

General Social Reward Response (Reward Sensitivity Via Emotional Dot Probe)

Timeframe: Baseline and post-injection (2.7 hrs)

General Social Reward Response (Reward Sensitivity Via Face Morphing Task)

Timeframe: Baseline and post-injection (2.8 hrs)

General Social Reward Response (Social Reward Motivation)

Timeframe: Baseline and post-injection (2 hrs)

Trial details

NCT IDNCT03848715

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-07-22

Results submitted2024-03-05

View on ClinicalTrials.gov More Anhedonia trials

Plain-language summary

Who can participate

Age range25 Years – 44 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Non-social (Monetary) Reward Response (Reward Learning and Sensitivity)

Timeframe: Baseline and post-injection (2.25 hrs)

Non-social (Monetary) Reward Response (Reward Motivation)

Timeframe: Baseline and post-injection (2.1 hrs)

Non-social (Monetary) Reward Response (Reward Sensitivity)

Timeframe: Baseline and post-injection (2.1 hrs)

General Social Reward Response (Reward Sensitivity Via Emotional Dot Probe)

Timeframe: Baseline and post-injection (2.7 hrs)

General Social Reward Response (Reward Sensitivity Via Face Morphing Task)

Timeframe: Baseline and post-injection (2.8 hrs)

General Social Reward Response (Social Reward Motivation)

Timeframe: Baseline and post-injection (2 hrs)