PK-AMIO study is a population pharmacokinetic study of Amiodarone in children in order to : * study the pharmacokinetic parameters (Pop PK) of Amiodarone in children; * identify covariates explaining the variability of these pharmacokinetic parameters; * study the relationship between the concentration, the efficacy of treatment and its tolerance to optimize the use of Amiodarone in pediatrics. Indeed, there is no consensus on the optimal oral dosage in children. Few pharmacokinetic studies have been performed with only a small number of patients per study. Our study will include 70 children aged 0 to 18 years old.
Age range
18 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Maximal Concentration (Cmax) of amiodarone
Timeframe: Hour 0 to Hour 24
Area under the plasma concentration versus time curve (AUC) of amiodarone
Timeframe: Hour 0 to Hour 24
Clearance of amiodarone
Timeframe: Hour 0 to Hour 24
Volume of distribution of amiodarone
Timeframe: Hour 0 to Hour 24
Half time of amiodarone
Timeframe: Hour 0 to Hour 24