Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol

Inclusion Criteria: * Participants were aged 18-65 years old, * American Society of Anesthesiologists (ASA) physical status I, II or III * scheduled to have urological surgery(would last longer than 1 h) * requiring general anesthesia. Exclusion criteria: * refused to participate in this study; * Unable to communicate normally because of consciousness alterations; * a history of allergy to opioids * contraindications to inhalational anesthesia * a family history of malignant hyperthermia * a history of alcohol or drug abuse * received central nervous system-active drugs * super obese as defined by a body mass index ≥40 kg/m2 * conditions liable to alter the pharmacokinetic and pharmacodynamic behaviors of the intravenous and inhalation anesthetics * previous head injury * neurologic * psychiatric disease * any disabling central nervous * cerebrovascular disease * using psychoactive * anti-convulsive medications at the time * unstable angina * manifested congestive heart failure * expected difficulty airway management