CompletedPhase 3

Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol

China146 participantsStarted 2020-01-20

Plain-language summary

This study purpose to compare analgesia efficiency of propofol combine with sevoflurane with propofol only using index of Nociception (NOX)

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participants were aged 18-65 years old, * American Society of Anesthesiologists (ASA) physical status I, II or III * scheduled to have urological surgery(would last longer than 1 h) * requiring general anesthesia. Exclusion criteria: * refused to participate in this study; * Unable to communicate normally because of consciousness alterations; * a history of allergy to opioids * contraindications to inhalational anesthesia * a family history of malignant hyperthermia * a history of alcohol or drug abuse * received central nervous system-active drugs * super obese as defined by a body mass index ≥40 kg/m2 * conditions liable to alter the pharmacokinetic and pharmacodynamic behaviors of the intravenous and inhalation anesthetics * previous head injury * neurologic * psychiatric disease * any disabling central nervous * cerebrovascular disease * using psychoactive * anti-convulsive medications at the time * unstable angina * manifested congestive heart failure * expected difficulty airway management

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

qNOX change

Timeframe: during operation

Trial details

NCT IDNCT03841812

SponsorChina International Neuroscience Institution

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-06-01

View on ClinicalTrials.gov More Nociceptive Pain trials

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.