Pulse Wave Velocity, Tacrolimus Time in Therapeutic Range and CV in African American Kidney Transplants

Inclusion Criteria: * Subjects who self-report their race/ethnicity as Black-non-Hispanic only (which may include self-reported African ancestry as African-American, Afro-Caribbean or African) * Subjects receiving a first or second deceased donor or living donor kidney transplant at the Hospital of the University of Pennsylvania * Subjects whose body mass index (BMI) ≥19 * Subjects who are sero-positive for Hepatitis B or C positive may also be enrolled. * Subjects whose concurrent immunosuppression at the time of transplant will be (generic or brand formulation) Mycophenolate mofetil (MMF, CellCept) or mycophenolic sodium (MPS, Myfortic®), either a standard prenisone taper or an early withdrawal protocol, and induction with rabbit-antithymocyte globulin (Thymoglobulin®). Exclusion Criteria: * Subjects who are greater than 75 years old * Known hypersensitivity to Tacrolimus and hydrogenated castor oil * Subjects who are not self-described as being of Black African descent and living in the United States * Subjects who self-report their race/ethnicity as Black-Hispanic or Multiracial * Subjects who are recipients of organ transplants other than kidney * Subjects who are recipients of third time or more kidney transplants * Subjects who are HIV positive at the time of pre-transplant screening * Subjects with recurrent focal segmental glomerulosclerosis (FSGS) * Subjects with any severe medical condition (including infection or severe liver disease) requiring acute or chronic…