Lyophilized Fecal Microbiota Transplantation for Recurrent Clostridioides Difficile Infection

Inclusion Criteria: * Age ≥ 12 years or older. * Able to provide informed consent. * Willing and able to comply with all the required study procedures. * A positive stool test for C. difficile toxin/gene using either PCR or enzyme immunoassay within 3 months of recruitment unless patient taking treatment specifically for CDI for more than 3 months. * History of at least ≥ 2 recurrent CDI where recurrence is defined as return of diarrhea consistent with CDI within 8 weeks following CDI symptom resolution for at least 24 hours after a minimum of 10-day course of standard antibiotic therapy for each episode and/or ongoing symptoms consistent with CDI\* (defined below) despite at least 7 days of treatment using oral vancomycin at a minimum dose of 250 mg four times daily. * Symptoms of CDI include: diarrhea defined as: 3 or more unformed bowel movements in 24 hours for a minimum of 2 days with no other causes for diarrhea Exclusion Criteria: * Planned or actively taking another investigational product * CDI symptom-free for 3 or more weeks following completion of CDI treatment * Patients with neutropenia with absolute neutrophil count \<0.5 x 109/L * Evidence of toxic megacolon or gastrointestinal perforation on abdominal x-ray * Active gastroenteritis due to Salmonella, Shigella, shiga toxin-producing E. coli, Yersinia or Campylobacter. * Presence of colostomy * Unable to tolerate FMT or enema for any reason. * Requiring systemic antibiotic therapy for more than 7 days. * Ac…