Stopped: Sponsor made a business decision to discontinue the study due to low accrual.
This is an open label Phase 2, 2-stage, 2-cohort study to evaluate rucaparib in combination with nivolumab in patients with high-grade serous or endometroid ovarian cancer. Patients entering the following cohorts must have BRCA mutational status confirmed by a central lab: * Cohort A1: No BRCA mutation in tumor; high level of LOH (loss of heterozygosity) * Cohort A2: BRCA mutation in tumor
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Objective Response Rate (ORR) by RECIST v1.1 as Assessed by the Investigator
Timeframe: From enrollment until disease progression (up to approximately 2 years)
The Effect of Rucaparib on the Immune Microenvironment
Timeframe: From enrollment to primary completion of study (up to approximately 2 years)