Carbon Ions Radiation Therapy for Resectable or Borderline Resectable Pancreas Adenocarcinoma

Inclusion Criteria: * histologic/cytologic diagnosis of exocrine pancreas tumour * resectable or borderline resectable exocrine pancreatic tumour (according to operability criteria) * no metastasis from US, CT, PET, MRI or laparotomy * Karnofsky index \>= 70 * stomach and duodenum not infiltrated by tumour * given informed consent to study procedures * Hb \> 9 g/dL, N\> 1500, PLT\> 100000 * creatininemia \< 1.5 mg/dL; bilirubinemia \< 1.5 times upper normal values; albumin \> 3 g/dL * DPD normal activity * contraception required and breast feeding not permitted Exclusion Criteria: * non resectable, locally advanced tumours * insular cells tumour * comorbidities excluding abdominal surgery and/or chemo- radiation therapy * known metastasis * DPD low activity * inability to attend study procedures and follow ups * pregnancy * previous diagnosis of other tumour with more disadvantageous prognosis then the study object * metallic biliary stent * metallic prothesis or any other condition to prevent from target volume individuation and dose calculation * clinical condition preventing from radiation therapy (i.e. infections in the irradiation area) * medical and/or psychical condition preventing from radiation therapy * past radiation therapy on abdomen.