The Mixed Phenotype of Asthma and COPD: the Overlap Syndrome (NCT03817333) | Clinical Trial Compass
CompletedNot Applicable
The Mixed Phenotype of Asthma and COPD: the Overlap Syndrome
Canada115 participantsStarted 2014-03
Plain-language summary
RATIONALE:
In asthmatic subjects, smoking can lead to several changes in disease characterictics. in smokers of more than 20 pack-years, chronic obstructive pulmonary disease (COPD) can be associated with asthma, also called asthma-COPD overlap syndrome (ACOS). Increasing data support the concept that ACOS is a clinical entity. However, this should be further studied in order to better target therapy.
AIM:
The objective of this study is to evaluate the comparative features of ACOS
METHODS:
This will be a descriptive study comparing the features of the ACOS with the features of asthmatic subjects with an incomplete reversibility of airway obstruction (IRAO).The study will be done over 1 or 2 visits (within a week interval), according to subjects' availability. The visit will include completion of different questionnaires (asthma control asthma quality of life, medical history, exacerbations, etc.), a thoracic examination, allergy skin-prick tests, spirometry and bronchodilator response, lung volumes and compliance measurements, exhaled nitric oxide measurement, blood sampling and a sputum induction.
Who can participate
Age range45 Years
SexALL
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Inclusion criteria
✓. Subjects aged 45 years and older.
✓. Free of any other respiratory condition, except for asthma and/or COPD, which may interfere with the tests.
✓. Asthma that requires a baseline treatment with inhaled corticosteroids and/or additional asthma medication.
✓. Free of respiratory infection in the 4 weeks preceding the study.
✓. No changes in the asthma and COPD-related medications in the 4 weeks preceding the study.
✓. If female, not pregnant (or lactating).
✓. Able to adhere to study procedures.
✓. Able and willing to provide written informed consent to participate in the study, in accordance with international conference on harmonization (ICH) good clinical practice (GCP) requirements.
Exclusion criteria
✕. With COPD without a past diagnosis of asthma.