Averting Complications of Proton Pump Inhibitor Therapy by Effervescent Calcium Magnesium Citrate

Inclusion Criteria: * Must have taken PPI (omeprazole or equivalent ≥ 20 mg/day, ≥ three times per week, for at least 2 months) * Expected to continue at a similar dosage * Stage 1 hypertension (with systolic blood pressure \<140 and diastolic \<90) * controlled diabetes mellitus Type II with HbA1C less than 7% Exclusion Criteria: * end-stage renal failure on dialysis * hypercalcemia * hypophosphatemia (serum P \< 2.5 mg/dL) * hypertension stage 2 or higher * diabetes Type II with HbA1C ≥ 7% * treatment with adrenocorticosteroids, diuretics, non-steroidal anti-inflammatory agents * regular dose of magnesium supplements, bisphosphonate, teriparatide, denosumab or selective estrogen receptor modulators. Inclusion/exclusion of other drugs or conditions will be considered on an individual basis.